Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/38088
Title: Synthensis and cytotoxicity of polyhydroxylated cholesterol derivatives
Authors: Dinh, Thi Ha
Doan, Lan Phuong
Pham, Quoc Long
Ngo, Dai Quang
Tran, Thi Thu Thuy
Keywords: Cholesterol
Cytotoxicity
Polyhydroxylated derivative
Issue Date: 2018
Series/Report no.: Vietnam Journal of Science and Technology;Vol.56(No.04) .- P.467–473
Abstract: Eight polyhydroxylated cholesterol derivatives (l-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibit human hepatocellular carcinoma cell line (Hep-G2) with IC50 values of 11.59, 11.89 and 6.87 µM' respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50: 2.28 µM.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/38088
ISSN: 2525-2518
Appears in Collections:Vietnam journal of science and technology

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