Synthensis and cytotoxicity of polyhydroxylated cholesterol derivatives

Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/38088

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DC Field	Value	Language
dc.contributor.author	Dinh, Thi Ha	-
dc.contributor.author	Doan, Lan Phuong	-
dc.contributor.author	Pham, Quoc Long	-
dc.contributor.author	Ngo, Dai Quang	-
dc.contributor.author	Tran, Thi Thu Thuy	-
dc.date.accessioned	2020-10-26T01:47:13Z	-
dc.date.available	2020-10-26T01:47:13Z	-
dc.date.issued	2018	-
dc.identifier.issn	2525-2518	-
dc.identifier.uri	https://dspace.ctu.edu.vn/jspui/handle/123456789/38088	-
dc.description.abstract	Eight polyhydroxylated cholesterol derivatives (l-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibit human hepatocellular carcinoma cell line (Hep-G2) with IC50 values of 11.59, 11.89 and 6.87 µM' respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50: 2.28 µM.	vi_VN
dc.language.iso	en	vi_VN
dc.relation.ispartofseries	Vietnam Journal of Science and Technology;Vol.56(No.04) .- P.467–473	-
dc.subject	Cholesterol	vi_VN
dc.subject	Cytotoxicity	vi_VN
dc.subject	Polyhydroxylated derivative	vi_VN
dc.title	Synthensis and cytotoxicity of polyhydroxylated cholesterol derivatives	vi_VN
dc.type	Article	vi_VN
Appears in Collections:	Vietnam journal of science and technology

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