Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/39574
Title: The Function of Lipinin the Wing Development of Drosophila me lanogaster
Authors: Tran, Duy Binh
Nishihara, Taisei
Pham, L. A. Tuan
Tran, Thanh Men
Kamei, Kaeko
Keywords: Drosophila
Lipin
DNA damage
Cell cycle
Wing development
Issue Date: 2019
Series/Report no.: International Journal of Molecular Sciences;Vol. 20, No. 13 .- P.1-18
Abstract: Lipin is evolutionarily conserved from yeast to mammals. Although its roles in lipid metabolism in adipocyte tissue, skeletal muscle, and the liver, and as a transcriptional co-activator are known, its functions during development are still under investigation. In this study, we analyzed the role of Drosophila lipin (dLipin) in development. Specifically, we showed that the tissue-selective knockdown of dLipin in the wing pouch led to an atrophied wing. Elevated DNA damage was observed in the wing imaginal disc of dLipin-knockdown flies. dLipin dysfunction induced accumulation of cells in S phase and significantly reduced the number of mitotic cells, indicating DNA damage-induced activation of the G2/M checkpoint. Reduced expression of cyclin B, which is critical for the G2 to M transition, was observed in the margin of the wing imaginal disc of dLipin-knockdown flies. The knockdown of dLipin led to increased apoptotic cell death in the wing imaginal disc. Thus, our results suggest that dLipin is involved in DNA replication during normal cell cycle progression in wing development of Drosophila melanogaster.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/39574
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