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Title: Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) for quantification of piroxicam in tablet dosage from as a green analytical method
Authors: Nguyen, Quoc Thang
Nguyen, Thi Mai Tho
Ho, Ngoc Nga
Nguyen, Thi Kim Phuong
Keywords: Piroxicam
Tablet dosage
Issue Date: 2020
Series/Report no.: Vietnam Journal of Chemistry;Vol 58, No 05 .- P.615-621
Abstract: A simple, rapid, precise, accurate, reproducible, economic and eco-friendly analytical method for the quantification of piroxicam in tablet dosage form, using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), has been developed. The measurements were based on the ATR technique, wherein there is no sample preparation, except for pulverizing the tablet, thereby eliminating the use of toxic Chemicals or solvents. The calibration curve of piroxicam was obtained by performing a linear regression analysis, using data from the direct ATR-FTIR measurement of percentage transmittance (%T), corresponding to the secondary peak at 1526.38 cm⁻¹ in the concentration (C) range of 25.18-93.63 mg/g. The linear regression equation obtained from the present data was represented by %T = -0.2178 C + 99.208 and was associated with a coefficient of determination (r²) of 0.998. The proposed method was validated for piroxicam in tablet form. The relative standard deviation percentage (%RSD) was found to be less than five, with a recovery percentage in the range of 96.0-99.3 %.
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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