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Title: Anthraquinones from Morinda longissima and their insulin mimetic activities via AMP-activated protein kinase (AMPK) activation
Authors: Phi, Hung Nguyen
Hà, Thị Kim Quy
Oh, Won-Keun
Williams, Darren R.
Jung, Da-Woon
Choi, Hong Seok
Seo, Ji Yeon
Yang, Jun-Li
Keywords: Morinda longissima
AMP-activated protein kinase (AMPK)
Glucose uptake
Issue Date: 2017
Series/Report no.: Bioorganic & Medicinal Chemistry Letters;27 .- p.40–44
Abstract: AMP-activated protein kinase (AMPK) activators are known to increase energy metabolism and to reduce body weight, as well as to improve glucose uptake. During for searching AMPK activators, a new anthraquinone, modasima A (10), along with eighteen known analogues (1–9 and 11–19) were isolated from an ethanol extract of the roots of Morinda longissima Y. Z. Ruan (Rubiaceae). Using the fluorescent tagged glucose analogues, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxy-D-glucose (2-NBDG), insulin mimetics were screened with compounds 1–19 in 3T3-L1 adipocytes. Among them, compounds 2, 8and 10 enhanced significantly glucose uptake into adipocytes and up-regulated the phosphorylated AMPK (Thr172) whereas the glucose uptake enhancing activities of compounds 2, 8 and 10 were abrogated by treatment of compound C, an AMPK inhibitor. Taken together, these anthraquinones showed the potential action as insulin mimetic to improve glucose uptake via activation of AMPK.
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