Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54578
Title: Nghiên cứu bào chế phytosome chứa polyphenol chiết xuất từ lá chè xanh (Camellia sinensis L.)
Authors: Nguyễn, Trọng Điệp
Nguyễn, Hoàng Hiệp
Nguyễn, Thị Thanh Hằng
Trần, Kim Thanh
Vũ, Bình Dương
Keywords: Green tea
Polyphenol
Phytosome
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 508 .- Tr.10-15
Abstract: A technical procedure was developed for preparation of phytosome dosage forms of the leaf polyphenols of the Vietnamese green tea (Camellia sinensis L.) with phosphatidylcholine (PC). The PP-PC complex forming reaction was optimized as follows: The reaction solvent - ethanol at 60%; the ratio of PP/PC -14; reaction temperature - 40°C; reaction time - 2 hrs. The obtained solutions were spray-dried to get phytosome products (PHY) in form of light yellow powder with the particle size of about a few micrometers; the total content of PP was 271.02 ± 13.92 mg/g, the content of PP in the complex 251.60 ± 12.91 mg/g, and the drug entrapment percentage 85.69 ± 4.40%. The complexity between PP and PC was demonstrated by DSC, FTIR, X-ray diffraction.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/54578
ISSN: 0866-7861
Appears in Collections:Dược học

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