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Title: Tổng hợp và thử tác dụng ức chế enzym glutaminyl cyclase của một số dẫn chất N-(4-methoxy-3-aminoalkyloxy- phenyl) thiourea mói
Authors: Trần, Phương Thảo
Hoàng, Văn Hải
Keywords: N-(4-Methoxy-3-aminoalkyloxy-phenyl)thiourea
Glutaminyl cyclase
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 509 .- Tr.33-36,87
Abstract: A new series of N-(4-methoxy-3-aminoalkyloxy-phenyl)thiourea were synthesized and their glutaminyl cyclase (QC) inhibitivity was fluorometrically evaluated The compounds were obtained via 6 or 7 steps by well-known reactions. Of these synthesized compounds, four (22-25) showed potential inhibitory activity on glutaminyl cyclase (QC) (ICX values of 9,026.8 nM).
ISSN: 0866-7861
Appears in Collections:Dược học

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