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Title: Biến cố kéo dài khoảng QTcF ở bệnh nhân sử dụng phác đồ có bedaquilin trong Chương trình Chống lao Quốc gia
Authors: Nguyễn, Thị Thủy
Nguyễn, Bảo Ngọc
Nguyễn, Thị Mai Phương
Hoàng, Thị Thanh Thủy
Nguyễn, Viết Nhung
Nguyễn, Mai Hoa
Vũ, Đình Hòa
Nguyễn, Hoàng Anh
Nguyễn, Quốc Thái
Keywords: Bedaquiline
QTcF prolongation
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 509 .- Tr.72-75
Abstract: Characteristics and risk factors for QTcF prolongation in patients on bedaquiline (Bdq)-containing regimen by the Vietnam’s National Programme for Antituberculosis were investigated. The study involved a cohort of adult patients with pre-XDR-TB and XDR-TB using Bdq-based regimen. The adverse events were managed under cohort event-monitoring and QT prolongation was evaluated according to Fredericks corrected QT value (QTcF). 64.6% of patients suffered from QTcF prolongation including 14.1% with severe events (QTcF > 500 ms). QTcF prolonging events were most likely to occur during the first two weeks with high Bdq doses. Really, cachexia, hypomagnesemia and hypokalaemia were independent risk factors of QTcF prolongation. These findings suggested close monitoring by electrocardiography to detect cardiovascular events, especially in those patients with electrolyte disturbances.
ISSN: 0866-7861
Appears in Collections:Dược học

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