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Title: Tổng hợp và thử hoạt tính gây độc tế bào ung thư của một số dẫn chất acylhydrazon mang khung 4(3H)-quinazolinon
Authors: Cao, Thị Cẩm Nhung
Lê, Công Trực
Cao, Việt Phương
Trần, Phương Thảo
Nguyễn, Hải Nam
Keywords: 4(3H)-Quinazolinone
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 510 .- Tr.3-7
Abstract: 5 novel procaspase-3 activating acylhydrazones synthesized incorporating 4(3H)-quinazolinones (Va-ej and biologically tested for cytotoxicity. These all 5 synthesized compounds exhibited significant cytotoxicity against the foilwing three human cancer cell lines: SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer. Of them, the most potent compound Vb displayed the highest cytotoxicity, as up to 4-fold as potent than 5-FU (5-fluorouracil).
ISSN: 0866-7861
Appears in Collections:Dược học

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