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Title: Nghiên cứu tổng hợp và thử hoạt tính kháng khuẩn một số dẫn chất Sulfonamid mới của benzimidazol
Authors: Nguyễn, Văn Hải
Nguyễn, Thị Thúy
Seyha, Kim
Sivmeiy, Chea
Đào, Nguyệt Sương Huyền
Nguyễn, Văn Giang
Nguyễn, Đình Luyện
Keywords: Sulfonamide
Issue Date: 2018
Series/Report no.: Tạp chí Dược học;Số 510 .- Tr.72-74,81
Abstract: Benzimidazole sulfonamides were synthesized by combination of two pharmacologically compatible moieties into a single molecule by attaching a sulfonamide moiety to a benzimidazole frame. Their structures are confirmed by 1H-NMR-spectroscopy and mass spectrometry. Of the 8 synthesized compounds, 7 (5a-7a, 4b-7b) were novel benzimidazole sulfonamides. The antibacterial activities of all the 8 synthesized compounds (4a-7a, 4b-7b) against standard strains of 5 Gram positive and 5 Gram negative bacteria were tested at 500 pg/mL by disk diffusion method. Of these, two sulfonamides (4a, 7b) showed promising antibacterial activity against both types of the tested bacteria.
ISSN: 0866-7861
Appears in Collections:Dược học

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