Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/55095
Title: Using bioinformatics to predict potential targets of microrna-144 in osteoarthritis
Authors: Ho, Thi Bich Phuong
Vien, Ngoc Thach
Luong, Hoang Ngan
Le, Thi Truc Linh
Keywords: Bioinformatics
MicroRNA-144
Osteoarthritis
Issue Date: 2018
Series/Report no.: Journal of Science HCM Open University;Vol. 8 No. 01 .- P.36-44
Abstract: MicroRNAs are short endogenous non-coding RNA molecules, typically 19-25 nucleotides in length, which negatively regulate gene expression through binding to 3’UTR of target mRNAs, leading to repression of protein translation or target mRNA degradation. MicroRNA-144 (miR-144) was found as an abnormal expression in various diseases, including osteoarthritis (OA). We have identified increased microRNA-144 expression in early phase and end stage of OA. However, the molecular mechanism of this increase has not been yet to be determined yet. Using bioinformatics tools, we found more than 4,000 mRNAs that are predicted to be potential direct targets of miR-144, including mRNAs involved in the critical signaling pathways in OA e.g. TGF(3/Smad2/3 and WNT/p-catenin. Results from this research provide information for future ex periments to validate miR-144 potential targets.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/55095
ISSN: 1859-3453
Appears in Collections:Khoa học Trường ĐH Mở Tp.HCM (Journal of Science HCM Open University)

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