Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/64079
Title: Applied bioinformatics tools for analysis of microrna-214 Expression and prediction of its potential targets genes in nasopharyngeal carcinoma
Authors: Nguyen, Hoang Danh
Thieu, Hong Hue
Quang, Trong Minh
K’, Trong Nghia
Nguyen, Thanh Tung
Phan, Dang Hoang Nam
Tran, Hoang Bao Tran
Lao, Duc Thuan
Keywords: MicroRNA
MiRNA-214
Nasopharyngeal carcinoma
Issue Date: 2019
Series/Report no.: Journal of Science HCM Open University;Vol. 9, No. 02 .- P.3-12
Abstract: MiRNA (microRNA) are short RNA molecules in length from 20 to 24 nucleotides that have been shown to play an important role in regulating gene expression in many different types of human cancer. Meanwhile, miRNA-214 is one of the known miRNAs involved in the formation of nasopharyngeal carcinoma (NPC) through overexpression that promotes proliferation and development of cancer cells. However, in Vietnam, the study of miR-214 related to NPC has not been conducted yet. With the aims to develop the further studies of miR-214 on NPC in Vietnamese patients, in this initial study, we conducted the analysis of miR-214 expression in previous publications, as well as the prediction of miR-214 potential target genes, which involved in many cellular pathways. Here we applied bioinformatics tools to predict miRNAs and their targets, and discuss the role of miR-214 in the context of human cancers. As the results, miR-214 acted as the oncogenic roles in NPC, relevanted to many pathways, such as cell proliferation, apoptosis, metastasis and invasion through the its target genes LTF, Bim, Box, LỈNC0086, etc. In conclusion, the use of computional approaches facilitate the further experimental validation of miRNAs in general, particularly miR-214, in Vietnamese NPC patients.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/64079
ISSN: 1859-3453
Appears in Collections:Khoa học Trường ĐH Mở Tp.HCM (Journal of Science HCM Open University)

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