Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/73544
Title: Effect of A20 on glucose dependent cell migration in acute lymphobeastic leukemia
Authors: Nguyen, Thi Xuan
Dang, Thanh Chung
Can, Van Mao
Keywords: Acule lymphoblastic leukemia
A20
Apoptosis
Migration
PBMCs
Issue Date: 2021
Series/Report no.: Vietnam Journal of Biotechnology;No. 02 .- P.229-236
Abstract: The present study, therefore, explored whether migration and apoptosis of peripheral blood mononuclear cells (PBMCs) and ALL blasts in high glucose conditions is regulated by A20. To this end, ALL blasts from blood samples of fifteen patients and PBMCs from healthy individuals in the absence of A20 were examined. Gene expression profile was determined by quantitative RT-PCR, cell apoptosis by flow cytometry, and cell migration by a transwell migration assay. As a result, the expression of A20 was inactivated in ALL blasts. Cell migration, but not apoptosis of ALL-blasts was enhanced when the cells were exposed to high glucose and dependent on A20 expression, the effects were abolished by using Nifuroxazide, a STAT inhibitor. In conclusion, A20 inhibited glucose-induced migration of ALL blasts through the STAT pathvvay. The effect might contribute to poorer survival of ALL patients, who develop hyperglycemia during therapy.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/73544
ISSN: 1811-4989
Appears in Collections:Công nghệ sinh học

Files in This Item:
File Description SizeFormat 
_file_
  Restricted Access
1.83 MBAdobe PDF
Your IP: 54.144.95.36


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.