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Title: The initial study of ebna-2 polymorphisms in nasopharyngeal carcinoma in Vietnam
Authors: Kha, Ngo Dong
Huynh, Thi Mong Tuyen
Lam, Hong Ngoc
Thieu, Hong Hue
Le, Quang Anh Tuan
Lao, Duc Thuan
Le, Huyen Ai Thuy
Keywords: E-2A
EBNA-2\ Nasopharyngeal carcinoma
Issue Date: 2018
Series/Report no.: Tạp chí Khoa học Trường ĐH Mở Tp.HCM (Journal of Science HCM Open University);Số 08(1) .- Tr.51-57
Abstract: Epstein-Barr virus (EBV) infection is the main cause of Nasopharyngeal Carcinoma (NPC). EBNA-2, one of the most important genes participating in the formation of NPC, also helps EBV evade an attack on the immune system. EBNA-2 has 4 variants including E2-A, E2-B, E2-C and E-2D, of which E2-A and E2-C are the characterized variants for NPC. This study aimed to evaluate the variations of EBNA-2 in NPC biopsy samples of Vietnamese patients. This initial study used 10 biopsy samples, which were positively confirmed to NPC, collected from Cho Ray Hospital. Nested PCR - nucleotide sequencing was applied to analyze the variants of EBNA-2. The results showed that 8 out of 10 samples, accounting for 80%, were positive to EBNA-2. Additionally, only two variants, E-2A and E-2C were detected in our study, in which, E2-A subtype was identified as the predominant subtype. These findings would provide initial data about potential contribution of EBNA-2 polymorphisms to etiology of NPC in Vietnamese population.
ISSN: 1859-3453
Appears in Collections:Khoa học Trường ĐH Mở Tp.HCM (Journal of Science HCM Open University)

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