Hoạt tính kháng nấm và thành phần hóa học của phân đoạn n-hexan thân và lá đương quy di thực Nhật Bản (Angelica acutiloba Sieb. et Zuce.) mọc tại Việt Nam

Abstract

The methanol extracts from the leaves and stems of Angelica acutiloba (Sieb. etZucc.) were investigated for antifungal activity against various pathogenic molds to medicinal plants. The n-hexane fractions showed a significant antifungal effect against Sclerotium rolfsii. Further, subjected to bioassay-guided isolation the fractions yielded three compounds: Z-ligustilide (1), stigmasterol (2) and cassipourol (3). Of these three compounds, ligustilide (1) was found strongly active against S. rolfsii, as a causal agent of stem rot on Atractyloides macrocephala, at the concentrations of 1 mg/mL and 0.5 mg/mL. Diterpene cassipourol (3) was isolated for the first time from A. acutiloba. These findings suggested an application of the aerial parts of A. acutiloba as a bio fungicide to control plant diseases of medicinal plants.