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https://dspace.ctu.edu.vn/jspui/handle/123456789/21698| Title: | Synthesis of novel artemisinin-triazole hybrids |
| Authors: | Le, Nhat Thuy Giang Dang, Thi Tuyet Anh Hoang, Thi Phuong Nguyen, Ha Thanh Nguyen, Van Tuyen |
| Keywords: | Dihydroartemisinin Triazole Hybrids |
| Issue Date: | 2018 |
| Series/Report no.: | Vietnam Journal of Chemistry;No 02 .- Page.167-171 |
| Abstract: | Several substituted triazole-artemisinin hybrids were synthesized based on ‘click’ chemistry between propargyl-substituted derivatives and artemisinin containing a 2-hydroxypropane unit. The structures of all obtained compounds were confirmed by means of IR, NMR, and MS spectroscopy. Four new hybrids were evaluated as cytotoxic agents, revealing an interesting anticancer activity of 1-(4-(3-Aminophenyl)-1H-1,2,3-triazol-1-yl)-3-(((3R,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyl-decahydro-12H-3,12-epoxy [1,2] dioxepino [4,3-i] isochromen-10- yl)oxy) propan-2-ol compound in KB and HepG2 cancer cell lines. |
| URI: | http://dspace.ctu.edu.vn/jspui/handle/123456789/21698 |
| ISSN: | 2525-2321 |
| Appears in Collections: | Vietnam Journal of Chemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 3.33 MB | Adobe PDF | ||
| Your IP: 18.216.124.8 |
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