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Title: | Modification of the vinylogous aldol condensation - Another approach to the synthesis of C(15)-alkylidene and benzylidene andrographolide derivatives |
Authors: | Ly, Minh Huy Huynh, Ha Ngoc Dung Nguyen, Dinh Hy Le, Bao Trang Duong, Trung Kien Tieu, Ly Nghiêm Tran, Thi Van Anh Truong, Ngoc Tuyên |
Keywords: | Andrographolide derivatives Dehydration Vinylogous aldol condensation Catalysts |
Issue Date: | 2019 |
Series/Report no.: | Vietnam Journal of Chemistry;Số 57(05) .- Tr.595-603 |
Abstract: | A two-step protocol for the synthesis of 15-alkylidene and benzylidene derivatives of 14-deoxy-l 1,12-didchydroandrographolide. which was conducted through a dehydration reaction of androerapholide and a vinylogous aldol condensation between α, β-unsaturated butenolide moiety and benzaldehyde derivatives lias been developed. Combining with various experiments on new catalysts for these reactions: the dehydration of andrographolidc by concentrated H₂SO₄ and the vinylogous aldol reaction by K₂CO₃ in McOH or a mixture of CH₃COOH/pyrrolidine in McOH, this research has determined the optimized conditions for those catalysts and the new approach to this aldol-like reaction. All compounds synthesized were characterized by the analysis of IR, NMR, HRMS spectra. |
URI: | http://dspace.ctu.edu.vn/jspui/handle/123456789/25387 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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Your IP: 18.191.186.72 |
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